Cushing's syndrome

A 17 years old Male pt , who is a student,  resident at nalgonda  presented with the chief complaints of increased itchy red lesions over the body 

Chief complaints: 
 1 . 1 and 1/2 year  ago  - itchy ring lesions over arm abdomen, thighs,groin region was absorbed 
 2 . 1 year ago - purple stretch marks all over abdomen, lower back ,upper limb things are absorbed  
3 . 6 months ago -  facial puffiness , abdominal                           distension are absorbed 
4 . 3 months ago - pedal edema , low back ache ,                    weight gain and decreased libido 
5 . 2 months ago -  loss of libido , erectile dysfunction 
6 . Recently.. feeling low , not feeling to talk to anyone 

History of present illness  : 
 
    Pt was aparently asymptomatic  1 and 1/2 year               back  then after eating some non-vegetarian food , he slowly developed  erythrmatous round lesions 
        Shape is annular , itchy all over abdomen , upper limb , groin , inner thigh region  

    then they went to a local RMP where he suggested ayurvedic medication and other creams  , pt used them for 2 months and lesions reduced abit 

after 2 months , he developed multiple hyper pigmented plaques over Lowe limbs, abdomen 

D. He visited to same place and used ayurvedic oils over lesions , used clobetasol ointment for 1yr over lesions 

E . 1 year back he noticed pink striae  over abdomen then on back , arms 
    Gradually increased  in size 
F .  Then he visited hospital  and used medications (ointment = miconazole and luliconazole ) , clobetasol also used 

G . Then abdominal distension and facial puffiness,  wt gain was absorbed  , but the didn't vist the hospital  

H . Since 3 months,  pedal edema  and low back ache was absorbed  , consulted a doctor who suggested  monteleukast,  luliconqzole ointment  for  tenia corporis  
I . 1 month ago , he stopped medication  and visited opd  with complaints of 
             Pink striae , easy fatigue , weakness , low back ache 

J . His brother also complainted that  , he is being  moody , feeling low, not going out , and not interacting with others 

Negative history  : 
     No chest pain , no sob , no palpitations 
   No h/o  Decreased urine 
     No DM , Asthama 
     
 Past history: 
    No similar past history is known 
  6 months back.. after using medication.. he developed  HYPERTENSION 

Personal history  : 
    Diet: since 8 months he eats only veg diet... before  he had a mixed diet 
      Sleep : not adequate  
    Bowel and bladder moments : normal 
 Food allergy  : 
     Allergic to spinach, fish and other non vegetarian foods. . Eggs 
     No addictions 
 Family history  : 
    No similar complaints are absorbed 
      No history of DM ,HTN  is absorbed in family 


General examination: 

O/E : Pt was c/c/c 

BP - 160/100 mmHg 

Pr - 96 BPM ,regular ,normovolemic .

Rr - 18/min 

Spo2- 98% on ra.

Weight - 63 kg.

Height - 175 cm.

NO pallor ,icterus ,cyanosis , clubbing, lymphadenopathy.

Pedal edema present - pitting type extending upto knee.

Abdominal distension present.

Moon face present

Pink striae noted over anterior abdominal wall and on low back and on upper arms and thighs.

Thin skin present . 

Poor healing noticed over leg ulcers and easy bruising noted .

Acne present over face .

Acanthosis nigrans noted over neck. 

GYNECOMASTIA PRESENT .

neck pad of fat present .

Sparse scalp hair .

.systemic examination: 

Skin examination - Multiple itchy erythematous annular leisons noted all over abdomen , upper limb ,groin and inner thigh region .

Multiple hyperpigmented plaques noted over bilateral lower limbs .


SYSTEMIC EXAMINATION :

CVS - S1S2 heard .No murmurs 

RS - BAE present .

No adventitious sounds .

P/A - Soft , distended .

No organomegaly .

Bowel sounds present .

CNS - HMF - INTACT                     R.       L 

MOTOR SYSTEM - POWER - UL 5/5      5/5

                                                  LL 5/5      5/5

Proximal muscles lower limb - power is 4/5 .


TONE - NORMAL.

REFLEXES - B. T.    S.     K.   A.   P

              R.     +2 +2.  +1.   +2. +1. FELXOR

               L.     +2. +2.  +2.    +2. +1. FLEXOR.

CRANIAL NERVES - NORMAL .

Difficulty in getting up from chair was noticed.


PROVISIONAL DIAGNOSIS -

 ? IATROGENIC CUSHINGS SYNDROME . 

TINEA CORPORIS .

DENOVO HTN .


INVESTIGATIONS :

CBP - HB - 13.4 g/dl 

TLC - 6,800

PLT - 1.5 lakhs.


RBS - 139 mg/dl 


CUE - ALBUMIN - +1 

SUGARS - NIL .

PUS CELLS - 3-4 

RBC - NIL .


LFT - TB -1.03

DB-0.21

ALBUMIN - 3.9


RFT - UREA - 22 

SERUM CREATININE -0.6

ELECTROLYTES - NA - 136 

K- 4 

CL-98 

USG ABDOMEN - NORMAL.

ECG - SINUS TACHYCARDIA 

LVH PRESENT.

On December 1st 2021 : 

1 yr back , when striae started 


28/5/21 





2nd follow up 

1st follow up 


Investigations 

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